4-Fluorobenzohydrazide → 3,5-bis-(4-Fluoro-phenyl)-1H-(1,2,4)triazole

反応式

[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[NH:7])=[CH:4][CH:3]=1.[F:11][C:12]1[CH:21]=[CH:20][C:15]([C:16]([NH:18]N)=O)=[CH:14][CH:13]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[N:8]=[C:16]([C:15]3[CH:20]=[CH:21][C:12]([F:11])=[CH:13][CH:14]=3)[NH:18][N:7]=2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 99724-Fluorobenzohydrazide

HCID 42952384-Fluorobenzamidine

生成物 1

HCID 866865153,5-bis-(4-Fluoro-phenyl)-1H-(1,2,4)triazole収率 71.2%

実験手順

4 g 4-fluoro-benzamidine was added to 4.5 g 4-fluoro-benzoic acid hydrazide and this mixture was melted. This mixture was crystallized with ethyl acetate to give 5.3 g of the desired compound. Rt: 1.55 min (method A), (M+H)+: 258

後処理

customThis mixture was crystallized with ethyl acetate

出典と根拠

ORDレコード: ord-a205307911b24c539cfb490c3a282420
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08889677B2

反応ノート

読み込み中…