Potassium Carbonate → 2-(3-Bromo-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

HRID 336379ノート

反応式

HRID 336379 の反応式
[Br:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:3]=1.Br[CH2:14][C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[CH2:19][CH2:18]1)=[O:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[N:3]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]([CH2:14][C:15]([N:17]2[CH2:18][CH2:19][N:20]([C:23]3[N:24]=[CH:25][CH:26]=[CH:27][N:28]=3)[CH2:21][CH2:22]2)=[O:16])[N:6]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 122170703-bromo-5-phenyl-1H-1,2,4-triazoleHCID 636798462-Bromo-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanone

生成物 1

HCID 866901712-(3-Bromo-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone収率 7.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

11 g 5-bromo-3-phenyl-1H-(1,2,4)triazole, 13.2 g 2-bromo-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanon and 28.2 g potassiumcarbonat in 300 mL acetone was stirred overnight at RT. The reaction was filtered and the filtrate was evaporated. The residue was purified by HPLC to give 1.45 g of the desired product. Rt: 1.08 min (method B), (M+H)+: 428/430

後処理

  1. filtrationThe reaction was filtered
  2. customthe filtrate was evaporated
  3. customThe residue was purified by HPLC

出典と根拠

ORDレコード
ord-fb91e35c99274963a0e062a6b23b58c1
出典データセット
uspto-grants-2014_11
特許番号
US08889677B2

反応ノート

読み込み中…