5-Hydroxymethyl-7-nitro-1H-indole-2-carboxylic acid → (R)-2-[(5-chloromethyl-7-nitro-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid methylester

HRID 336466ノート

反応式

HRID 336466 の反応式
O[CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([N+:12]([O-:14])=[O:13])[CH:11]=1)[NH:8][C:7]([C:15](O)=O)=[CH:6]2.[ClH:18].[CH3:19][O:20][C:21](=[O:36])[CH2:22][C@@H:23]([NH2:35])[CH2:24][S:25]CC1C=CC(OC)=CC=1>>[CH3:19][O:20][C:21](=[O:36])[CH2:22][C@@H:23]1[CH2:24][S:25][C:15]([C:7]2[NH:8][C:9]3[C:5]([CH:6]=2)=[CH:4][C:3]([CH2:2][Cl:18])=[CH:11][C:10]=3[N+:12]([O-:14])=[O:13])=[N:35]1

参加物

3

反応物 2

HCID 594480875-Hydroxymethyl-7-nitro-1H-indole-2-carboxylic acidHCID 66974362(R)-3-amino-4-(4-methoxy-benzylsulfanyl)-butyric acid methyl ester hydrochloride

生成物 1

HCID 59543007(R)-2-[(5-chloromethyl-7-nitro-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid methylester

実験手順

5-Hydroxymethyl-7-nitro-1H-indole-2-carboxylic acid prepared in Preparation and (R)-3-amino-4-(4-methoxy-benzylsulfanyl)-butyric acid methyl ester hydrochloride prepared in Preparation 27 were reacted according to the same procedures as Steps B and C of Preparation 40 to give the title compound.

後処理

  1. customprepared in Preparation 27
  2. customwere reacted
  3. customaccording to the same procedures as Steps B and C of Preparation 40

出典と根拠

ORDレコード
ord-3c53b81eed6c49e68de10e8f81c0ceb0
出典データセット
uspto-grants-2014_11
特許番号
US08889691B2

反応ノート

読み込み中…