HCID 178524534、化合物 → HCID 178516122、化合物
反応式
[OH:1][C:2]1[N:10]=[C:9]([OH:11])[C:8]([F:12])=[CH:7][C:3]=1C(O)=O>O1CCOCC1>[OH:11][C:9]1[C:8]([F:12])=[CH:7][CH:3]=[C:2]([OH:1])[N:10]=1参加物
3
実験手順
2,6-Dihydroxy-5-fluoronicotinic acid (2.25 g) was dissolved in dioxane (25 mL) and refluxed for 15 minutes. After being cooled, the solvent was evaporated to obtain Compound 4a (1.65 g). Yield: 99%1 H-NMR (DMSOd6, δPPM): 7.26 (1H, dd, J=7.7 Hz, J=11.0 Hz), 5.45 (1H, d, J=6.6 Hz)
後処理
- temperaturerefluxed for 15 minutes
- temperatureAfter being cooled
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-40a616a8e52d443581beadd67e6f338b
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889699B2
反応ノート
読み込み中…