Tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate → tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate

HRID 336533ノート

反応式

HRID 336533 の反応式
[C:1]([CH:3]1[CH2:6][C:5]2([CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]2)[CH2:4]1)#[N:2]>[Ni]>[NH2:2][CH2:1][CH:3]1[CH2:4][C:5]2([CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]2)[CH2:6]1

参加物

3

反応物 1

HCID 56962170Tert-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate

生成物 1

HCID 68001449tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate収率 107.7%

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

The process is performed according to the procedure described in Example 8 (step 8.2.). Starting with 0.20 g (0.85 mmol) of ter-butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate, (isomer 1b), described in Example 8 (step 8.1.) and a catalytic amount of Raney nickel, 0.22 g of product is obtained in the form of a yellow oil, which is used without further purification in the following step.

出典と根拠

ORDレコード
ord-9034527d6ca24057bd172657fac08b9b
出典データセット
uspto-grants-2014_11
特許番号
US08889702B2

反応ノート

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