tert-Butyl 2-azido-6-azaspiro[3.4]octane-6-carboxylate → tert-Butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate
反応式
[N:1]([CH:4]1[CH2:7][C:6]2([CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8]2)[CH2:5]1)=[N+]=[N-]>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[NH2:1][CH:4]1[CH2:5][C:6]2([CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8]2)[CH2:7]1参加物
3
実験手順
The process is performed according to the procedure described in Example 6 (step 6.4). Starting with 1.33 g (5.30 mmol) of tert-butyl 2-azido-6-azaspiro[3.4]octane-6-carboxylate (isomer 2′) and 0.54 g (2.65 mmol) of Lindlar catalyst (PdCaCO3), 0.70 g of product is obtained in the form of an oil.
出典と根拠
- ORDレコード
- ord-9b53e02da1154478abc6228db4266c52
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889702B2
反応ノート
読み込み中…