化工社化工社 化学情報印刷レポート · 研究参考用
Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol | HCID 64556 | — |
| 反応物 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 反応物 | 3,5-Dimethylpyrazole-4-boronic acid, pinacol ester | HCID 16217713 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazole | HCID 86681254 | — |
反応手順
To a solution of 1-adamantanemethanol (0.090 g), 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.160 g) and cyanomethylenetributylphosphorane (0.215 g) were added and stirred together in toluene (2 mL) at room temperature. After stirring overnight the reaction was loaded directly onto silica gel and eluted using a gradient of 2% to 20% ethyl acetate/hexanes to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889675B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-63ff3c89dfbb4fed8261f7af31e51bea |
| 出典メモ | uspto-grants-2014_11 |