Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → 1-(tricyclo[3.3.1.13,7]dec-2-ylmethyl)-4-iodo-1H-pyrazole

反応式

[C:1]12(CO)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[I:13][C:14]1[CH:15]=[N:16][NH:17][CH:18]=1.[CH3:19]C1C(B2OC(C)(C)C(C)(C)O2)=C(C)NN=1>>[CH:1]12[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]3)[CH:8]1[CH2:19][N:16]1[CH:15]=[C:14]([I:13])[CH:18]=[N:17]1)[CH2:10]2

参加物

反応物 3

HCID 64556Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol

HCID 770224-Iodopyrazole

HCID 162177133,5-Dimethylpyrazole-4-boronic acid, pinacol ester

生成物 1

HCID 866812581-(tricyclo[3.3.1.13,7]dec-2-ylmethyl)-4-iodo-1H-pyrazole

実験手順

The title compound was prepared by substituting EXAMPLE 10A for 1-adamantanemethanol and 4-iodopyrazole for 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole in EXAMPLE 2A.

出典と根拠

ORDレコード: ord-83f8606d1f1c471cbee8ccf8705a7c0d
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08889675B2

反応ノート

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