Methanol → Methyl tricyclo[3.3.1.13,7]decane-2-carboxylate
反応式
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[C:11]([OH:13])=[O:12])[CH2:8]2.CO.[CH3:16][Si](C=[N+]=[N-])(C)C>C(OCC)(=O)C>[CH:3]12[CH2:9][CH:7]3[CH2:6][CH:5]([CH2:10][CH:1]([CH2:8]3)[CH:2]1[C:11]([O:13][CH3:16])=[O:12])[CH2:4]2参加物
5
実験手順
To a solution of adamantane-2-carboxylic acid 1 (0.486 g, 2.70 mmol) in ethyl acetate (10 mL)/methanol (5 mL) was dropwise added (trimethylsilyl)diazomethane (1.348 ml, 2.70 mmol) and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated and purified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes).
後処理
- concentrationThe reaction mixture was concentrated
- custompurified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes)
出典と根拠
- ORDレコード
- ord-c789df7a103c489a92c5e6de38ea8c13
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889675B2
反応ノート
読み込み中…