Bromine → 2-Bromo-1-(2-fluoro-4-hydroxyphenyl)ethanone

HRID 336824ノート

反応式

HRID 336824 の反応式
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([OH:8])=[CH:7][C:2]=1[F:1])=[O:11]

参加物

4

反応物 2

HCID 24408BromineHCID 27249122'-Fluoro-4'-hydroxyacetophenone

生成物 1

HCID 223137872-Bromo-1-(2-fluoro-4-hydroxyphenyl)ethanone収率 75%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 5 g (32.44 mmol) of 1-(2-fluoro-4-hydroxyphenyl)ethanone dissolved in 140 ml of anhydrous dioxane are added dropwise 5.7 g (35.68 mmol, 1.83 ml) of dibromine at 0° C. under argon. The reaction mixture is brought to 70° C. for 3 h. The solvent is concentrated by vacuum evaporation and the solid is recrystallized in 40 ml of 1,2-dichloroethane to yield 5.67 g (75%) of 2-bromo-1-(2-fluoro-4-hydroxyphenyl)ethanone in the form of a violet solid.

後処理

  1. concentrationThe solvent is concentrated by vacuum evaporation
  2. customthe solid is recrystallized in 40 ml of 1,2-dichloroethane

出典と根拠

ORDレコード
ord-81eebc2984e44665b564f461b2b24d9d
出典データセット
uspto-grants-2014_11
特許番号
US08889711B2

反応ノート

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