関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 5-(Hydroxymethyl)furfural | HCID 237332 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-(Bromomethyl)-2-furaldehyde | HCID 11970491 | 87% |
反応手順
To a solution of 3.4 g (26.7 mmol) of 5-(hydroxymethyl)furan-2-carboxaldehyde and 7.78 g (29.4 mmol) of triphenylphosphine in 300 ml of dichloromethane at −5° C. are added 5.28 g (29.4 mmol) of N-bromosuccinimide in 10 min. The mixture is stirred at −5° C. for 30 min. The mixture is then concentrated and the residue is purified by chromatography on silica (cyclohexane/AcOet: 7:3) to yield 4.38 g (87%) of 5-(bromomethyl)furan-2-carboxaldehyde in the form of a brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08889711B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-3384ac6afaf846c187cbe481e7a64ad1 |
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| 出典メモ | uspto-grants-2014_11 |
|---|
