関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl 6-chloro-4-hydroxy-3-quinolinecarboxylate | HCID 718113 | — |
| 反応物 | HCID 178479711 | HCID 178479711 | — |
| 生成物 | Ethyl 4,6-dichloroquinoline-3-carboxylate | HCID 1479087 | — |
反応手順
Ethyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (19.8 mmol) and phosphorus (V) oxychloride (99.3 mmol) was stirred and heated to 125° C. for 12 hours. The mixture was cooled to ambient temperature and the phosphorus (V) oxychloride was evaporated. The crude product was used without further purification. MS m/z 271.80 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08889706B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-7f5f899c7f9c44a4b10cfe57c6ae087e |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
