Dimethylamine → 6-Chloro-N,N-dimethylnicotinamide
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[CH3:11][NH:12][CH3:13]>C(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:12]([CH3:13])[CH3:11])=[O:7])=[CH:4][N:3]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
In a 500 mL round-bottomed flask, 6-chloronicotinoyl chloride (8 g, 45.5 mmol, Eq: 1.00) was dissolved in DCM (200 ml) under argon and cooled to 0° C. To this solution, dimethylamine (90.9 ml of 2M in THF, 182 mmol, Eq: 4) was added drop-wise over 15 min maintaining the temperature below 10° C. The ice bath was removed and the reaction was stirred for 3 h.
後処理
- temperaturemaintaining the temperature below 10° C
- customThe ice bath was removed
出典と根拠
- ORDレコード
- ord-3430a7d4f61c4caab0f557ffb543068e
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889682B2
反応ノート
読み込み中…