Hydrochloric Acid → Indeno(1,2-b)indole
反応式
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl.[C:12]1(C)[CH:17]=[CH:16][C:15]([NH:18]N)=[CH:14][CH:13]=1.Cl>CCO>[CH:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[CH:3]=[C:2]1[C:16]3[CH:17]=[CH:12][CH:13]=[CH:14][C:15]=3[N:18]=[C:1]12参加物
5
実験手順
1-Indanone (30.6 g, 232 mmol), p-tolylhydrazine hydrochloride (37.0 g, 233 mmol) in EtOH (350 mL), and aqueous HCl (12 N, 18 mL) are mixed and the mixture is heated to reflux for 90 min. The mixture is cooled and filtered, and the solid is washed with EtOH (600 mL) and then by 20% aqueous EtOH (400 mL), and finally by hexane (200 mL). The off-white solid is dried under vacuum (36.5 g, 72%).
後処理
- temperaturethe mixture is heated
- temperatureto reflux for 90 min
- temperatureThe mixture is cooled
- filtrationfiltered
- washthe solid is washed with EtOH (600 mL)
- customThe off-white solid is dried under vacuum (36.5 g, 72%)
出典と根拠
- ORDレコード
- ord-291cef9a942f450aa2dbd74cde24d56e
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429635B2
反応ノート
読み込み中…