Hydrochloric Acid → Indeno(1,2-b)indole

HRID 33733

反応式

HRID 33733 の反応式
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl.[C:12]1(C)[CH:17]=[CH:16][C:15]([NH:18]N)=[CH:14][CH:13]=1.Cl>CCO>[CH:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[CH:3]=[C:2]1[C:16]3[CH:17]=[CH:12][CH:13]=[CH:14][C:15]=3[N:18]=[C:1]12

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 67351-IndanoneHCID 125044-Methylphenylhydrazine monohydrochloride

生成物 1

HCID 12963293Indeno(1,2-b)indole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-Indanone (30.6 g, 232 mmol), p-tolylhydrazine hydrochloride (37.0 g, 233 mmol) in EtOH (350 mL), and aqueous HCl (12 N, 18 mL) are mixed and the mixture is heated to reflux for 90 min. The mixture is cooled and filtered, and the solid is washed with EtOH (600 mL) and then by 20% aqueous EtOH (400 mL), and finally by hexane (200 mL). The off-white solid is dried under vacuum (36.5 g, 72%).

後処理

  1. temperaturethe mixture is heated
  2. temperatureto reflux for 90 min
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. washthe solid is washed with EtOH (600 mL)
  6. customThe off-white solid is dried under vacuum (36.5 g, 72%)

出典と根拠

ORDレコード
ord-291cef9a942f450aa2dbd74cde24d56e
出典データセット
uspto-grants-2008_09
特許番号
US07429635B2

関連ノート

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