3-Fluoropentane-2,4-dione → 1-(2-Benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazole

HRID 337353ノート

反応式

HRID 337353 の反応式
Cl.[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][NH2:17])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:18][CH:19]([C:23](=O)[CH3:24])[C:20](=O)[CH3:21]>C(O)C>[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:16]1[C:23]([CH3:24])=[C:19]([F:18])[C:20]([CH3:21])=[N:17]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 116266523-Fluoropentane-2,4-dioneHCID 12891836(2-(Benzyloxy)phenyl)hydrazine hydrochloride

生成物 1

HCID 867032601-(2-Benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazole収率 70.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

500 mg of 2-benzyloxyphenyl hydrazine hydrochloride and 251 mg of 3-fluoropentane-2,4-dione were added to 12 ml of ethanol, and heated at reflux for 1.5 hours. The reaction solution was concentrated under reduced pressure as it is and purified using silica gel column chromatography (hexane:ethyl acetate=6:1 to 5:1) to yield 417 mg of the title compound.

後処理

  1. temperatureheated
  2. temperatureat reflux for 1.5 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure as it
  4. custompurified

出典と根拠

ORDレコード
ord-88a8dce911be426ba17e9c018908fdd3
出典データセット
uspto-grants-2014_11
特許番号
US08889727B2

反応ノート

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