3-Chloro-2,4-pentanedione → 4-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-hydroxyphenyl acetate

HRID 337361

反応式

HRID 337361 の反応式
CC1C=CC(S(O)(=O)=O)=CC=1.[C:12]([O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][NH2:23])=[C:18]([OH:24])[CH:17]=1)(=[O:14])[CH3:13].C(OC1C=CC(N)=C(O)C=1)(=O)C.[Cl:37][CH:38]([C:42](=O)[CH3:43])[C:39](=O)[CH3:40]>>[C:12]([O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:42]([CH3:43])=[C:38]([Cl:37])[C:39]([CH3:40])=[N:23]2)=[C:18]([OH:24])[CH:17]=1)(=[O:14])[CH3:13]

参加物

4

反応物 3

HCID 743283-Chloro-2,4-pentanedioneHCID 197705154-Amino-3-hydroxyphenyl acetateHCID 867032644-Hydrazinyl-3-hydroxyphenyl acetate 4-methylbenzenesulfonate

生成物 1

HCID 867032664-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-hydroxyphenyl acetate収率 4.2%

実験手順

30 mg of the title compound was prepared in a manner similar to Example 54b) by using 4-hydrazinyl-3-hydroxyphenyl acetate 4-methylbenzenesulfonate (0.9 g), which was prepared from 4-amino-3-hydroxyphenyl acetate (1.0 g) in a manner similar to Example 54a), and 3-chloropentane-2,4-dione (1.2 g).

出典と根拠

ORDレコード
ord-1008ad6c6c734e1496f468c928548bbc
出典データセット
uspto-grants-2014_11
特許番号
US08889727B2

関連ノート

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