関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lawesson's reagent | HCID 87949 | — |
| 反応物 | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethylfuran-2-yl)-methanone | HCID 11244101 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione | HCID 11508298 | — |
反応手順
A solution of (4-isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanone (Example 1, 1 equiv.) and Lawesson's reagent (2.1 equiv.) in THF is heated at reflux (70° C.) for 48 h. The reaction is cooled to room temperature and the solvent is removed in vacuo. Chromatography of the residue on a silica gel column using 1-6% 2 M NH3 in MeOH/DCM) provides the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07429659B2 |
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| 出典データセット | uspto-grants-2008_09 |
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| ORD ID | ord-1110e46f7d2f433e8f777fa8a0a330e1 |
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| 出典メモ | uspto-grants-2008_09 |
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