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2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole → 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole | HCID 10516668 | — |
| 反応物 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 生成物 | 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole | HCID 10491805 | 52.2% |
反応手順
By the method used in Example 1, Part D, 630 g (2.3 mmol) of 2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole was O-demethylated by treating it with 9 mL of 1M BBr3 /CH2Cl2. The crude product was chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 316 mg (52% yield) of 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733923 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-90e6c368bccf4e26954b7d2f6022a3b3 |
| 出典メモ | uspto-grants-1998_03 |