Dimethylformamide → 1,3-Bis(3-methoxypropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

HRID 337613ノート

反応式

HRID 337613 の反応式
[CH:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)=[O:2].Br[CH2:12][CH2:13][CH2:14][O:15][CH3:16].[CH2:17]1[CH2:27]CN2C(=NCCC2)C[CH2:18]1.CN([CH:31]=[O:32])C>>[CH3:16][O:15][CH2:14][CH2:13][CH2:12][N:7]1[CH:8]=[C:3]([CH:1]=[O:2])[C:4](=[O:10])[N:5]([CH2:18][CH2:17][CH2:27][O:32][CH3:31])[C:6]1=[O:9]

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 3045905-FormyluracilHCID 5245511-Bromo-3-methoxypropane

生成物 1

HCID 866459191,3-Bis(3-methoxypropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

実験手順

To a DMF (0.35 M) solution of 5-formyluracil (1 eq.) was added sequentially at 0° C. 1-bromo-3-methoxypropane (2.2 eq.) and DBU (2.2 eq.). The resulting solution was stirred at RT for 72 h. The volatiles were then removed in vacuo. The crude product mixture thus obtained was directly subjected to purification by way of column chromatography (SiO2, EtOAc) to afford the title compound as a yellow oil.

後処理

  1. customThe volatiles were then removed in vacuo
  2. customThe crude product mixture thus obtained
  3. customwas directly subjected to purification by way of column chromatography (SiO2, EtOAc)

出典と根拠

ORDレコード
ord-cde0f4ebe46b4a7b8cbb8028d434ae96
出典データセット
uspto-grants-2014_11
特許番号
US08889714B2

反応ノート

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