4-Chloro-3-methylphenol → HCID 22467254、化合物

HRID 337618ノート

反応式

HRID 337618 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH3:9].C([O-])([O-])=O.[K+].[K+].Br[CH2:17][CH2:18][O:19][CH3:20]>CN(C=O)C.O.CCOCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:17][CH2:18][O:19][CH3:20])=[CH:4][C:3]=1[CH3:9]

参加物

7

反応物 3

HCID 17324-Chloro-3-methylphenolHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl ether

生成物 1

HCID 22467254HCID 22467254、化合物

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 4-chloro-3-methylphenol (1 eq.) in DMF (0.7 M) was added K2CO3 (1.2 eq.). The mixture was stirred at 50° C. for 5 min before 1-bromo-2-methoxyethane (1.5 eq.) was added. After 2 h at 70° C., the reaction mixture was cooled down to RT and then diluted with water and ether. The organic phase was separated and washed sequentially with 2 N aq. NaOH, water and brine. The organic extract was dried over Na2SO4, filtered and the filtrate concentrated in vacuo to afford the title compound as a yellowish oil.

後処理

  1. additionwas added
  2. customThe organic phase was separated
  3. washwashed sequentially with 2 N aq. NaOH, water and brine
  4. extractionThe organic extract
  5. dry with materialwas dried over Na2SO4
  6. filtrationfiltered
  7. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-ce8696ec85d046e4b4bc07a5a4c1936d
出典データセット
uspto-grants-2014_11
特許番号
US08889714B2

反応ノート

読み込み中…