化工社化工社 化学情報印刷レポート · 研究参考用
4-Isopropylaniline → N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Isopropylaniline | HCID 7464 | — |
| 反応物 | 4-(Dimethylamino)Benzaldehyde | HCID 7479 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | Ammonium chloride ethyl acetate | HCID 86583716 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(4-(Dimethylamino)benzyl)-4-isopropylbenzenamine | HCID 21957887 | — |
反応手順
To a 0.33 M solution of 4-(dimethylamino)benzaldehyde in THF at 0° C. was added 1.1 equiv of 4-isopropylaniline followed by 1.5 equiv of sodium triacetoxyborohydride. After allowing the reaction to warm to room temperature overnight, this mixture was poured into a separatory funnel containing aqueous NH4Cl/EtOAc. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated. The crude material was further purified by flash chromatography, eluting with a gradient from 100% hexanes to 10% EtOAc/hexanes to provide the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429666B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-c2f206464e554652baed0836d7fe1452 |
| 出典メモ | uspto-grants-2008_09 |