化工社化工社 化学情報印刷レポート · 研究参考用
Dabco → 2-Chloro-N-(2,4-dimethoxybenzyl)-4,5-difluoro-N-(pyrimidin-4-yl)benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | 2-Chloro-4,5-difluorobenzenesulfonyl chloride | HCID 2773523 | — |
| 反応物 | N-(2,4-Dimethoxybenzyl)pyrimidin-4-amine | HCID 63362995 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Chloro-N-(2,4-dimethoxybenzyl)-4,5-difluoro-N-(pyrimidin-4-yl)benzenesulfonamide | HCID 89963165 | 21.1% |
反応手順
The reaction and aftertreatment were conducted in the same manner as in Example 14b by using the N-(2,4-dimethoxybenzyl)pyrimidin-4-amine (150 mg, 0.611 mmol) prepared in Example 14a, 2-Chloro-4,5-difluorobenzenesulfonyl chloride (302 mg, 1.22 mmol), 1,4-diazabicyclo[2.2.2]octane (137 mg, 1.22 mmol) and acetonitrile (5.0 mL), to yield the title compound (58.8 mg, 21%) as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889741B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-1321217a95e34d0eb753de3bf97c059c |
| 出典メモ | uspto-grants-2014_11 |