化工社化工社 化学情報印刷レポート · 研究参考用
Dabco → HCID 89963213、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | 3-Cyano-4-fluorobenzenesulfonyl chloride | HCID 2778908 | — |
| 反応物 | N-(2,4-Dimethoxybenzyl)pyrimidin-4-amine | HCID 63362995 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 89963213 | HCID 89963213 | 19.1% |
反応手順
The reaction and aftertreatment were conducted in the same manner as in Example 14b by using the N-(2,4-dimethoxybenzyl)pyrimidine-4-amine (600 mg, 2.44 mmol) prepared in Example 14a, 3-cyano-4-fluorobenzenesulfonyl chloride (1.07 g, 4.87 mmol), 1,4-diazabicyclo[2.2.2]octane (549 mg, 4.89 mmol) and acetonitrile (12 mL), to yield the title compound (200 mg, 19%) as a colorless amorphous solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889741B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-47dfa1f2fc1349b2a3c0a7f4fb1ad343 |
| 出典メモ | uspto-grants-2014_11 |