Dabco → HCID 89963213、化合物

HRID 337751

反応式

HRID 337751 の反応式
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][N:8]=1.[C:19]([C:21]1[CH:22]=[C:23]([S:28](Cl)(=[O:30])=[O:29])[CH:24]=[CH:25][C:26]=1[F:27])#[N:20].N12CCN(CC1)CC2>C(#N)C>[C:19]([C:21]1[CH:22]=[C:23]([S:28]([N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=2[O:2][CH3:1])[C:7]2[CH:12]=[CH:11][N:10]=[CH:9][N:8]=2)(=[O:30])=[O:29])[CH:24]=[CH:25][C:26]=1[F:27])#[N:20]

参加物

5

反応物 3

HCID 9237DabcoHCID 27789083-Cyano-4-fluorobenzenesulfonyl chlorideHCID 63362995N-(2,4-Dimethoxybenzyl)pyrimidin-4-amine

生成物 1

HCID 89963213HCID 89963213、化合物収率 19.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The reaction and aftertreatment were conducted in the same manner as in Example 14b by using the N-(2,4-dimethoxybenzyl)pyrimidine-4-amine (600 mg, 2.44 mmol) prepared in Example 14a, 3-cyano-4-fluorobenzenesulfonyl chloride (1.07 g, 4.87 mmol), 1,4-diazabicyclo[2.2.2]octane (549 mg, 4.89 mmol) and acetonitrile (12 mL), to yield the title compound (200 mg, 19%) as a colorless amorphous solid.

後処理

  1. customThe reaction and aftertreatment

出典と根拠

ORDレコード
ord-47dfa1f2fc1349b2a3c0a7f4fb1ad343
出典データセット
uspto-grants-2014_11
特許番号
US08889741B2

関連ノート

読み込み中…