Cesium carbonate → 6-Chloro-4-(1,4-dioxaspiro[4.5]dec-6-en-6-yl)pyridazin-3-amine

関与物質

役割	名称	HCID	仕込み量
反応物	Cesium carbonate	HCID 10796	—
反応物	1,4-Dioxane	HCID 31275	—
反応物	3-Amino-4-bromo-6-chloropyridazine	HCID 22024419	—
反応物	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-6-ene	HCID 89963451	—
触媒	HCID 178418397	HCID 178418397	—
溶媒	Water	HCID 962	—
生成物	6-Chloro-4-(1,4-dioxaspiro[4.5]dec-6-en-6-yl)pyridazin-3-amine	HCID 89962119	43%

反応手順

The reaction and aftertreatment were conducted in the same manner as in Example 39a by using the 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-6-ene (0.64 g, 2.40 mmol) prepared in Example 82a, 4-bromo-6-chloropyridazin-3-amine (0.50 g, 2.40 mmol), tetrakis(triphenylphosphine)palladium (0) (0.14 g, 0.12 mmol), cesium carbonate (1.72 g, 5.29 mmol), dioxane (8.0 mL) and water (4.0 mL), to yield the title compound (275.7 mg, 43%) as a colorless oil.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08889741B2
出典データセット	uspto-grants-2014_11
ORD ID	ord-4e8760d21a7944e6a9304d36acc17e4a
出典メモ	uspto-grants-2014_11