Potassium Carbonate → HCID 89963326、化合物

HRID 337911

反応式

HRID 337911 の反応式
[F:1][C:2]1[CH:7]=[C:6]([O:8][C@H:9]2[CH2:13][CH2:12][CH2:11][C@@H:10]2[C:14]2[N:18]([CH3:19])[N:17]=[CH:16][CH:15]=2)[CH:5]=[CH:4][C:3]=1[S:20]([NH2:23])(=[O:22])=[O:21].[F:24][C:25]1[N:30]=[C:29](F)[CH:28]=[CH:27][N:26]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:1][C:2]1[CH:7]=[C:6]([O:8][C@H:9]2[CH2:13][CH2:12][CH2:11][C@@H:10]2[C:14]2[N:18]([CH3:19])[N:17]=[CH:16][CH:15]=2)[CH:5]=[CH:4][C:3]=1[S:20]([NH:23][C:27]1[CH:28]=[CH:29][N:30]=[C:25]([F:24])[N:26]=1)(=[O:21])=[O:22]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 1377162,4-DifluoropyrimidineHCID 89963518HCID 89963518、化合物

生成物 1

HCID 89963326HCID 89963326、化合物収率 70.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The reaction and aftertreatment were conducted in the same manner as in Example 111d by using the 2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cyclopentyl]oxy}benzenesulfonamide (0.16 g, 0.47 mmol) prepared in Example 114c, 2,4-difluoropyrimidine (0.16 g, 1.41 mmol), potassium carbonate (0.26 g, 1.88 mmol) and DMF (4.7 mL), to yield the title compound (143.6 mg, 70%) as a colorless amorphous solid.

後処理

  1. customThe reaction and aftertreatment

出典と根拠

ORDレコード
ord-d65347fd72d34332b2542c5cfc22c51f
出典データセット
uspto-grants-2014_11
特許番号
US08889741B2

関連ノート

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