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Lithium Hexamethyldisilazide → HCID 89962088、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 反応物 | 2,4,6-Trifluorobenzenesulfonyl chloride | HCID 2776983 | — |
| 反応物 | tert-butyl N-(1,3-thiazol-4-yl)carbamate | HCID 53241636 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 89962088 | HCID 89962088 | 78% |
反応手順
The reaction and aftertreatment were conducted in the same manner as in Example 86a by using tert-butyl 1,3-thiazol-4-ylcarbamate (Synthesis, 2010, 3152-3162; 1.00 g, 4.99 mmol), lithium bis(trimethylsilyl)amide (1.0 M solution in THF; 5.99 mL, 5.99 mmol), 2,4,6-trifluorobenzenesulfonyl chloride (1.38 g, 5.99 mmol) and THF (15 mL), to yield the title compound (1.53 g, 78%) as a pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889741B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-54d4b39789334dc0b2febdb3aa5de7f5 |
| 出典メモ | uspto-grants-2014_11 |