Chloromethyl Methyl Ether → HCID 89963013、化合物
反応式
[NH:1]1[CH:5]=[C:4]([C@@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@H:7]2[OH:12])[CH:3]=[N:2]1.[CH3:13][O:14][CH2:15]Cl>CN(C=O)C>[CH3:13][O:14][CH2:15][N:1]1[CH:5]=[C:4]([C@@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@H:7]2[OH:12])[CH:3]=[N:2]1参加物
4
実験手順
To a solution of the (1R,2S)-2-(1H-pyrazol-4-yl)cyclohexanol (170 mg, 1.02 mmol) prepared in Example 169b in DMF (5.0 mL), chloromethyl methyl ether (0.078 mL, 1.02 mmol) was added, and the reaction solution was stirred at room temperature for 2 hours. The reaction solution was vacuum concentrated, and the residue was then purified with silica gel chromatography (hexane/ethyl acetate=7:3) to yield the title compound (132 mg, 61%) as a colorless solid.
後処理
- concentrationconcentrated
- customthe residue was then purified with silica gel chromatography (hexane/ethyl acetate=7:3)
出典と根拠
- ORDレコード
- ord-4ba879dbb1574a0491c8f5f3d7caa458
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889741B2
反応ノート
読み込み中…