Hydrochloric Acid → HCID 178517041、化合物

HRID 338041

反応式

HRID 338041 の反応式
[N:1]1[C:2](=[O:10])[CH:3]=[C:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[CH:5]2.Br[C:12]1[CH:20]=[C:19]2[C:15]([C:16](=O)[C:17](=[O:21])[NH:18]2)=[CH:14][CH:13]=1.Cl>C(O)(=O)C>[CH:13]1[CH:12]=[CH:20][C:19]2[NH:18][C:17](=[O:21])/[C:16](=[C:3]3\[C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=4[NH:1][C:2]\3=[O:10])/[C:15]=2[CH:14]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 957161H-Indole-2,3-dione, 6-bromo-HCID 17904787Indol-2-one

生成物 1

HCID 178517041HCID 178517041、化合物収率 95%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Separately adding 6-brome indolone (500 mg, 2.36 mmol), 6-bromoisatin (533 mg, 2.36 mmol of isatin), 15 mL glacial acetic acid and 0.1 mL HCl into a flask, heating and refluxing for 24 hours. Stop the reaction and cooling to room temperature, filtering to obtain a solid, and then washing the solid by water, ethanol, and ethyl acetate. Drying the final product in a vacuum drying box, get brown 6,6′-bidromo isoindigo, the yield was 95%.

後処理

  1. temperatureheating
  2. temperaturerefluxing for 24 hours
  3. customthe reaction
  4. filtrationfiltering
  5. customto obtain a solid
  6. washwashing the solid by water, ethanol, and ethyl acetate
  7. dry with materialDrying the final product in a vacuum
  8. customdrying box

出典と根拠

ORDレコード
ord-33af6b66062c439f94a228dd305491d4
出典データセット
uspto-grants-2014_11
特許番号
US08889825B2

関連ノート

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