Hydrochloric Acid → 2-(4-Bromophenyl)pyrrolidine hydrochloride

HRID 338426

反応式

HRID 338426 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2C(OC(C)(C)C)=O)=[CH:4][CH:3]=1.[ClH:20]>CO>[ClH:20].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 53407516tert-Butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate

生成物 1

HCID 534075152-(4-Bromophenyl)pyrrolidine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

The suspension of tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate (1.2 g, 3.7 mmol) in anhydrous methanol (10 mL) was added hydrogen chloride in methanol (20 mL, 4.0M in MeOH) under nitrogen. The reaction was stirred at room temperature for 1.5 hours. The mixture was concentrated to afford the title compound (0.99 g, quantitative yield) which was used without purification in the next step.

後処理

  1. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-fee60a7d31904186b2bff237eb169f36
出典データセット
uspto-grants-2014_11
特許番号
US08889730B2

関連ノート

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