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(1-(4-Bromophenyl)cyclobutyl)methanol → 4,6-difluoro-5-(4-(1-(hydroxymethyl)cyclobutyl)phenyl)-1H-indole-3-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1-(4-Bromophenyl)cyclobutyl)methanol | HCID 58538689 | — |
| 反応物 | 5-Bromo-4,6-difluoro-1H-indole-3-carbaldehyde | HCID 86698578 | — |
| 生成物 | 4,6-difluoro-5-(4-(1-(hydroxymethyl)cyclobutyl)phenyl)-1H-indole-3-carbaldehyde | HCID 86698845 | — |
反応手順
[1-(4-bromophenyl)cyclobutyl]methanol, prepared as described in Example 72 (steps 1 and 2), is treated with 5-bromo-4,6-difluoro-1H-indole-3-carbaldehyde, prepared as described in Example 6 (steps 1-4), in a manner similar as described in Example 6 step 5 to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08889730B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-11765295e5174708a5b780ec3251fd15 |
| 出典メモ | uspto-grants-2014_11 |