4-Bromo-2-fluorobenzaldehyde → 4-Bromo-2-methoxybenzaldehyde

HRID 338516

反応式

HRID 338516 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH3:11][O-:12].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:12][CH3:11])[CH:3]=1

参加物

4

反応物 2

HCID 1435174-Bromo-2-fluorobenzaldehydeHCID 10942334Sodium Methoxide

生成物 1

HCID 110530414-Bromo-2-methoxybenzaldehyde収率 94.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-bromo-2-fluorobenzaldehyde (25.0 g, 0.123 mol) and sodium methoxide (13.99 g, 0.2600 mol) in dry methanol (250 mL) was stirred at reflux temperature for 16 hours. The mixture was concentrated and the residue was partitioned between dichloromethane (500 mL) and water (250 mL). The organic layers were combined and dried over sodium sulfate then concentrated in vacuo to provide the title compound as yellow solid (25 g, 94.5%).

後処理

  1. temperatureat reflux temperature for 16 hours
  2. concentrationThe mixture was concentrated
  3. customthe residue was partitioned between dichloromethane (500 mL) and water (250 mL)
  4. dry with materialdried over sodium sulfate
  5. concentrationthen concentrated in vacuo

出典と根拠

ORDレコード
ord-f10ddf9e31c6467c9c7d5611ebcdeb79
出典データセット
uspto-grants-2014_11
特許番号
US08889730B2

関連ノート

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