化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 4-(2-Quinolin-2-yl-ethyl)-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(2-Quinolin-2-yl-ethyl)-benzoic acid methyl ester | HCID 68575869 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(2-Quinolin-2-yl-ethyl)-benzoic acid | HCID 68576307 | 86% |
反応手順
To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid methyl ester (680 mg) in THF (11 ml)/methanol (3 ml) was added 1N sodium hydroxide solution (4.67 ml). The reaction mixture stirred for 4 h. and the pH adjusted to 3. The white solid was filtered to provide the title compound (550 mg, 86%). MS: (M+H m/z=278.1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429665B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-0cc8621753b5413c8299f25a9bc3a651 |
| 出典メモ | uspto-grants-2008_09 |