関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | (4-(Benzyloxy)phenyl)hydrazine monohydrochloride | HCID 3016725 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(4-Benzyloxy-phenyl-2H-pyrazol-3-yl]-pyridine | HCID 86606416 | — |
反応手順
To a solution of 3-Dimethylamino-1-pyridin-4-yl-propenone (590 mg) in methanol (10 ml) was added acetic acid (0.5 ml) and (4-Benzyloxy-phenyl)-hydrazine hydrogen chloride (836 mg) and the reaction mixture heated to 60° C. for 6 h. The reaction mixture was poured into saturated sodium bicarbonate, extracted with ethyl acetate, dried magnesium sulfate, filtered and concentrated. Purification via combiflash MPLC provided the title compound (795 mg). MS: (M+H m/z=328.1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07429665B2 |
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| 出典データセット | uspto-grants-2008_09 |
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| ORD ID | ord-59dbb7e24d53454c96698a6b1ff946d5 |
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| 出典メモ | uspto-grants-2008_09 |
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