Ethanol → (2RS,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid
反応式
C(O)C.[OH:4][C:5]1[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:6]=1[CH:7]=O.O.Cl.[NH2:16][C@H:17]([C:20]([OH:22])=[O:21])[CH2:18][SH:19].C([O-])(=O)C.[Na+]>O>[OH:4][C:5]1[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:6]=1[CH:7]1[NH:16][C@H:17]([C:20]([OH:22])=[O:21])[CH2:18][S:19]1参加物
6
実験手順
In a mixed solvent including ethanol (10 ml) and water (10 ml), a solution including 2,4-dihydroxybenzaldehyde (943 mg, 6.83 mmol), L-cysteine hydrochloride monohydrate (1.0 g, 5.69 mmol), and sodium acetate (495 mg, 6.03 mmol) was stirred at room temperature for 14 hours. The produced precipitate was filtered, and a filter cake was washed with water, and ethyl acetate to obtain the target product that is a solid white (1.316 g, 95.8%).
後処理
- filtrationThe produced precipitate was filtered
- washa filter cake was washed with water, and ethyl acetate
- customto obtain the target product that
出典と根拠
- ORDレコード
- ord-9299a74564c14a0f848dd393c14e3a7c
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889881B2
反応ノート
読み込み中…