3,5-Dibromo-4-Hydroxybenzaldehyde → 2,6-Dibromo-4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenol

HRID 338787

反応式

HRID 338787 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:11])[C:9]=1[OH:10])[CH:5]=O.[NH2:12][C:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:14]=1[SH:23]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2[S:23][C:14]3[CH:15]=[CH:16][C:17]([C:19]([F:20])([F:21])[F:22])=[CH:18][C:13]=3[N:12]=2)[CH:7]=[C:8]([Br:11])[C:9]=1[OH:10]

参加物

4

反応物 2

HCID 181003,5-Dibromo-4-HydroxybenzaldehydeHCID 880422-Amino-4-(trifluoromethyl)benzenethiol

生成物 1

HCID 1361834942,6-Dibromo-4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenol

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

In a N,N-dimethylformamide (DMF) solvent, a suspension of 3,5-dibromo-4-hydroxybenzaldehyde (1.0 eq.) and 2-amino-4-(trifluoromethyl)benzenethiol (1.0 eq.) was heated at a temperature of 100° C. After cooling, DMF was removed therefrom under reduced pressure. Methylene chloride was added to the resultant solid, and the produced precipitate was filtered, and washed with methylene chloride to obtain a solid target product.

後処理

  1. temperatureAfter cooling
  2. customDMF was removed
  3. additionMethylene chloride was added to the resultant solid
  4. filtrationthe produced precipitate was filtered
  5. washwashed with methylene chloride
  6. customto obtain a solid target product

出典と根拠

ORDレコード
ord-b681226bcc2444e1987d034dffcf3148
出典データセット
uspto-grants-2014_11
特許番号
US08889881B2

関連ノート

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