4-(Quinolin-2-ylmethoxy)aniline → 4-(Quinolin-2-ylmethoxy)phenylhydrazine

HRID 33885ノート

反応式

HRID 33885 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1.[N:20]([O-])=O.[Na+].[Sn]>Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([NH:19][NH2:20])=[CH:17][CH:18]=1

参加物

5

反応物 3

HCID 27475694-(Quinolin-2-ylmethoxy)anilineHCID 5352426Tin atomHCID 23668193Sodium Nitrite

生成物 1

HCID 152250684-(Quinolin-2-ylmethoxy)phenylhydrazine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒2 回

実験手順

To a suspension of 4-(Quinolin-2-ylmethoxy)-phenylamine (1.73 g) in 30 mL of concentrated HCl at 0° C. was added sodium nitrite (531 mg). After 3 h, tin chlrodie (3.95 g) was dissolved in 20 mL of concentrated HCl and added slowly dropwise and the reaction mixture stirred at ambient temperature for 18 h. The reaction mixture was filtered and the solid dried to provide the title compound as the HCL salt (3.94 g). MS: (M+H m/z=266.3).

後処理

  1. additionadded slowly dropwise
  2. filtrationThe reaction mixture was filtered
  3. customthe solid dried

出典と根拠

ORDレコード
ord-95238443306142f79127fd0dcfbeea54
出典データセット
uspto-grants-2008_09
特許番号
US07429665B2

反応ノート

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