1,4-Dioxane → Methyl 2-formylquinoline-7-carboxylate
反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][CH:8]=2)[N:3]=1.[O:16]1CCOCC1>O>[CH:1]([C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][CH:8]=2)[N:3]=1)=[O:16]参加物
4
実験手順
To a solution of methyl 2-methylquinoline-7-carboxylate (0.99 g, 4.92 mmol) in dioxane (60 mL) and water (0.6 mL) was added SeO2 (0.66 g, 5.90 mmol) and the mixture was stirred at reflux for 2 hours. After cooling to ambient temperature, the solid was removed by filtration and washed with DCM. The filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (1:4 hexane/ethyl acetate) to give methyl 2-formylquinoline-7-carboxylate (0.75 g, 70.8%) as a solid.
後処理
- temperatureat reflux for 2 hours
- customthe solid was removed by filtration
- washwashed with DCM
- concentrationThe filtrate was concentrated under reduced pressure
- customThe residue was purified by flash chromatography on silica gel (1:4 hexane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-c2d880793db94ae6b978fb0d7ffb8609
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889704B2
反応ノート
読み込み中…