Acetic Acid → HCID 70984126、化合物
反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([CH:12](C(OCC)=O)[C:13]([O:15]CC)=[O:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl.C(O)(=O)C>O>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([CH2:12][C:13]([OH:15])=[O:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
5
実験手順
A solution of diethyl 2-(2-methylquinolin-8-yl)malonate (2.34 g, 7.77 mmol), 6 N HCl (7.77 mL, 46.6 mmol) in water, and acetic acid (7.77 mL) was heated at 106° C. for 18 hours. After cooling to ambient temperature, the solvent was removed under reduced pressure to give 2-(2-methylquinolin-8-yl)acetic acid (1.56 g, 99.8%) as a solid.
後処理
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-ae21fd09de2e4248bd81f912a9f729f0
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889704B2
反応ノート
読み込み中…