tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate → tert-butyl N-[(3S)-1-[(1R)-2,2,2-trifluoro-1-[6-[(2E)-2-[[7-(2-methoxyethoxy)-8-methylquinolin-2-yl]methylidene]hydrazinyl]pyridin-3-yl]ethyl]pyrrolidin-3-yl]carbamate

HRID 338924ノート

反応式

HRID 338924 の反応式
[F:1][C:2]([F:26])([F:25])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10][NH2:11])=[CH:8][CH:9]=1.[CH3:27][O:28][CH2:29][CH2:30][O:31][C:32]1[C:41]([CH3:42])=[C:40]2[C:35]([CH:36]=[CH:37][C:38]([CH:43]=O)=[N:39]2)=[CH:34][CH:33]=1>C(O)C>[F:26][C:2]([F:25])([F:1])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:23])[CH3:21])[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10]/[N:11]=[CH:43]/[C:38]2[CH:37]=[CH:36][C:35]3[C:40](=[C:41]([CH3:42])[C:32]([O:31][CH2:30][CH2:29][O:28][CH3:27])=[CH:33][CH:34]=3)[N:39]=2)=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 86707414tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamateHCID 867074527-(2-Methoxyethoxy)-8-methylquinoline-2-carbaldehyde

生成物 1

HCID 140628976tert-butyl N-[(3S)-1-[(1R)-2,2,2-trifluoro-1-[6-[(2E)-2-[[7-(2-methoxyethoxy)-8-methylquinolin-2-yl]methylidene]hydrazinyl]pyridin-3-yl]ethyl]pyrrolidin-3-yl]carbamate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

tert-Butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate (98.0 mg, 0.261 mmol) and 7-(2-methoxyethoxy)-8-methylquinoline-2-carbaldehyde (64 mg, 0.261 mmol) were stirred in ethanol at ambient temperature for 24 hours. The reaction was concentrated and used as is in the next step.

後処理

  1. concentrationThe reaction was concentrated

出典と根拠

ORDレコード
ord-ac2e2b853a334949a094bddf3df37f07
出典データセット
uspto-grants-2014_11
特許番号
US08889704B2

反応ノート

読み込み中…