1,4-Dioxane → 7-(2-Hydroxyethyl)quinoline-2-carbaldehyde
反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([CH2:12][CH2:13][OH:14])=[CH:7][CH:8]=2)[N:3]=1.[O:15]1CCOCC1>O>[OH:14][CH2:13][CH2:12][C:6]1[CH:5]=[C:4]2[C:9]([CH:10]=[CH:11][C:2]([CH:1]=[O:15])=[N:3]2)=[CH:8][CH:7]=1参加物
4
実験手順
2-(2-methylquinolin-7-yl)ethanol (0.220 g, 1.17 mmol) was dissolved in dioxane (5 mL) and water (0.05 mL). The reaction was treated with SeO2 (0.156 g, 1.41 mmol) and the mixture was heated to reflux for 2 hours. After cooling to ambient temperature, the solid was removed by filtration and washed with DCM. The filtrate was concentrated and the residue was purified by flash chromatography on silica gel (ethyl acetate/hexanes 5:1) to give 7-(2-hydroxyethyl)quinoline-2-carbaldehyde (0.21 g, 1.04 mmol, 89% yield) as a solid.
後処理
- temperaturethe mixture was heated
- temperatureto reflux for 2 hours
- customthe solid was removed by filtration
- washwashed with DCM
- concentrationThe filtrate was concentrated
- customthe residue was purified by flash chromatography on silica gel (ethyl acetate/hexanes 5:1)
出典と根拠
- ORDレコード
- ord-fa410f2bf75e4e12b55027bda56be480
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889704B2
反応ノート
読み込み中…