Iodo benzene diacetate → tert-butyl (3S)-1-((1R)-2,2,2-trifluoro-1-(3-(3-fluoro-7-(2-methoxyethoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate

反応式

[F:1][C:2]([F:26])([F:25])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10][NH2:11])=[CH:8][CH:9]=1.[F:27][C:28]1[C:29]([CH:43]=O)=[N:30][C:31]2[C:36]([CH:37]=1)=[CH:35][CH:34]=[C:33]([O:38][CH2:39][CH2:40][O:41][CH3:42])[CH:32]=2.C(O)(=O)C.C(O)(=O)C.IC1C=CC=CC=1>CCO.C(Cl)Cl>[F:26][C:2]([F:25])([F:1])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:23])[CH3:21])[CH2:13]1)[C:4]1[CH:9]=[CH:8][C:7]2[N:6]([C:43]([C:29]3[C:28]([F:27])=[CH:37][C:36]4[C:31](=[CH:32][C:33]([O:38][CH2:39][CH2:40][O:41][CH3:42])=[CH:34][CH:35]=4)[N:30]=3)=[N:11][N:10]=2)[CH:5]=1