Hydrochloric Acid → HCID 86653078、化合物

HRID 339131

反応式

HRID 339131 の反応式
[O:1]=[C:2]([NH:22][CH:23]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=1)[C:24]([F:27])([F:26])[F:25])/[CH:3]=[CH:4]/[C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH:10]([NH:14]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2.Cl.O>O1CCOCC1>[NH2:14][CH:10]1[C:11]2[C:7](=[CH:6][C:5](/[CH:4]=[CH:3]/[C:2]([NH:22][CH:23]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:35])([F:36])[F:37])[CH:29]=3)[C:24]([F:25])([F:26])[F:27])=[O:1])=[CH:13][CH:12]=2)[CH2:8][CH2:9]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86653077tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

生成物 1

HCID 86653078HCID 86653078、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2.2 g of tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate were dissolved in 40 ml of dioxane and admixed with 10 ml of semisaturated hydrochloric acid, and stirred at room temperature overnight. The reaction mixture was admixed with water and extracted with ethyl acetate. The combined organic phases were dried over sodium sulphate, filtered and concentrated. This gave 1.5 g of (2E)-3-(1-amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}-acrylamide (82%).

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe combined organic phases were dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-97bd1eda03cd4c65b483de5236d2ebf3
出典データセット
uspto-grants-2014_11
特許番号
US08889878B2

関連ノート

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