関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Azidotrimethylsilane | HCID 78378 | — |
| 反応物 | 4-[2-(4-Methoxyphenyl)ethynyl]pyridine | HCID 4595253 | — |
| 生成物 | HCID 178489101 | HCID 178489101 | 53% |
反応手順
4-(2-(4-methoxyphenyl)ethynyl)pyridine (1.48 g, 7.1 mmol) and trimethylsilylazide (2.5 g, 21.3 mmol) were combined in a sealed tube which was heated 48 h in a 150° C. oil bath. The mixture was chromatographed on silica using an ethyl acetate-hexanes gradient giving a yellow solid (950 mg, 53%). 1H NMR (CDCl3, 400 mHz) δ 8.50 (d, 2H, J=5.8 Hz), 7.60 (d, 2H, J=5.8 Hz), 7.36 (d, 2H, J=8.7 Hz), 6.92 (d, 2H, J=8.7 Hz), 3.81 (s, 3H), 2.80 (br, 1H). MS (AP+) m/e 253 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07429665B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-fbfc539e405f4b0a87a9c6ec5d541498 |
|---|
| 出典メモ | uspto-grants-2008_09 |
|---|
