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D-Leucine, methyl ester → (R)-methyl 4-methyl-2-(5-methyl-1H-indole-2-carboxamido)pentanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | D-Leucine, methyl ester | HCID 89967 | — |
| 反応物 | 5-methyl-1H-indole-2-carboxylic acid | HCID 259188 | — |
| 生成物 | (R)-methyl 4-methyl-2-(5-methyl-1H-indole-2-carboxamido)pentanoate | HCID 7322438 | 50% |
反応手順
Prepared in a similar manner to example 4 using 5-Methyl-1H-indole-2-carboxylic acid and D-leucine methyl ester. Yield: 50%. NMR (500 MHz, CDCl3): 0.98 (d, 3H, J=6.3 Hz), 1.00 (d, 3H, J=6.1 Hz), 2.44 (s, 3H), 3.784 (s, 3H), 4.87 (m, 1H), 6.56 (d, 1H, J=8.39 Hz), 6.85 (dd, 1H, J=1.94 Hz, J=0.68 Hz), 7.12 (dd, 1H, J=8.46 Hz, J=1.55 Hz), 7.31 (d, 1H, J=8.45 Hz), 7.42 (s, 1H). MS (MH+, 303).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895050B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-53cf107493c94d989e7feaf1986b11e0 |
| 出典メモ | uspto-grants-2014_11 |