関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trimethyl orthoacetate | HCID 15050 | — |
| 反応物 | 3-Amino-4-hydroxybenzoic acid | HCID 65083 | — |
| 反応物 | 2-Methyl-1,3-benzoxazole-5-carboxylic acid | HCID 23282284 | — |
| 生成物 | HCID 57527791 | HCID 57527791 | 80% |
反応手順
2-methyl benzooxazol-5-carboxylic acid: A mixture of 3-amino-4-hydroxybenzoic acid (1.5 g, 9.79 mmol) and trimethyl orthoacetate (15 mL, large excess) was heated at 65° C. for 5 hrs under argon. The reaction mixture was cooled to room temperature, filtered, washed with hexanes. The filtrate was concentrated in vacuo to afford the product as a yellow solid (1.4 g, 80%): 1H NMR (500 MHz, CD3OD) δ 8.26 (d, J=1.7 Hz, 1H), 8.07 (dd, J=8.5, 1.6 Hz, 1H), 7.67 (d, J=8.2 Hz, 1H), 2.67 (s, 1H); MS (APCI, M+1): 178.10.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08895050B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-77586c13ce834404bfd10b1312d178a8 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
