3,4-Dimethylbenzoic acid → (R)-N-(1-hydroxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide

反応式

[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=O.N[NH:13][C@@H:14]([CH2:19][OH:20])[CH2:15][CH:16]([CH3:18])[CH3:17]>>[OH:20][CH2:19][C@H:14]([NH:13][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([CH3:11])=[C:2]([CH3:1])[CH:3]=1)[CH2:15][CH:16]([CH3:18])[CH3:17]

参加物

反応物 2

HCID 120733,4-Dimethylbenzoic acid

HCID 86597565(R)-aminoleucinol

生成物 1

HCID 39352414(R)-N-(1-hydroxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide収率 75%

実験手順

(R)—N-(1-hydroxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide was prepared in a similar manner as described in example 4 using 3,4-dimethylbenzoic acid and with (R)-aminoleucinol. Yield: 75%. MS (M+H, 250.3).

出典と根拠

ORDレコード: ord-68997b4afbcf4dcaa1a97585d74276ea
出典データセット: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08895050B2

反応ノート

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