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Hydrochloric Acid → Cni H1594
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 3'-Aminoacetophenone | HCID 7417 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Cni H1594 | HCID 133110 | 78.5% |
反応手順
Compound No. 15: A suspension of m-aminoacetophenone (2.7 g) and 2-amino-4-chloro-6-methylpyrimidine (2.87 g) in 40 mL water was treated with 1.7 mL concentrated HCl and heated at reflux for 1 hour. Addition of 40 mL 1N KOH gave a light buff solid, which was filtered out and dried to give 3.8 g 4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine, mp 196°-98° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733932 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-b3ee4c95f2d64d7599ce13045545da3c |
| 出典メモ | uspto-grants-1998_03 |