p-Toluic acid, 2,3,5,6-tetrafluoro- → N-(2,4-dimethylpentan-3-yl)-2,3,5,6-tetrafluoro-4-methylbenzamide

HRID 339413

反応式

HRID 339413 の反応式
[CH3:1][CH:2]([CH:4]([NH2:8])[CH:5]([CH3:7])[CH3:6])[CH3:3].[F:9][C:10]1[C:15]([F:16])=[C:14]([C:17](O)=[O:18])[C:13]([F:20])=[C:12]([F:21])[C:11]=1[CH3:22]>>[CH3:1][CH:2]([CH:4]([NH:8][C:17](=[O:18])[C:14]1[C:13]([F:20])=[C:12]([F:21])[C:11]([CH3:22])=[C:10]([F:9])[C:15]=1[F:16])[CH:5]([CH3:7])[CH3:6])[CH3:3]

参加物

3

反応物 2

HCID 69548p-Toluic acid, 2,3,5,6-tetrafluoro-HCID 777023-Pentanamine, 2,4-dimethyl-

生成物 1

HCID 57527966N-(2,4-dimethylpentan-3-yl)-2,3,5,6-tetrafluoro-4-methylbenzamide

実験手順

Prepared in a similar manner to Example 162 using 2,4-dimethylpentan-3-amine and 2,3,5,6-tetrafluoro-p-toluic acid (90%). 1H NMR (CDCl3) δ 0.91 (d, J=6.7 Hz, 6H), 1.00 (d, J=6.8 Hz, 6H), 1.85 (m, 2H), 2.29 (m, 3H), 3.82 (m, 1H), 5.52 (bd, 1H). MS (306.1, M+H) m. p. 184-187° C.

出典と根拠

ORDレコード
ord-301c7b2a330240b3b0d9ca47c0d5485b
出典データセット
uspto-grants-2014_11
特許番号
US08895050B2

関連ノート

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