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3-(Trifluoromethyl)benzoyl chloride → 3-Trifluoromethyl-N-[4-(6-methoxybenzothiazol-2-yl)-phenyl]-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)benzoyl chloride | HCID 75257 | — |
| 反応物 | 4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline | HCID 391870 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3-Trifluoromethyl-N-[4-(6-methoxybenzothiazol-2-yl)-phenyl]-benzamide | HCID 67312136 | 86.3% |
反応手順
Prepared as described in the Amide Coupling section using 2-(4-aminophenyl)-6-methoxybenzothiazole (0.06 g, 0.23 mmol) and 3-trifluoromethylbenzoyl chloride (0.054 g, 0.26 mmol) in dry pyridine (7.5 ml) to give the title compound (0.085 g, 85%) as a colourless solid after work-up.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08895313B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-9960f492bb52472990dc749ad7477ea2 |
| 出典メモ | uspto-grants-2014_11 |